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Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007

Year: 2024

Type: article

Abstract: Three new terpenoid derivatives (1S,6R,7S)-hydrobenzosydowic acid (1), (1 R,6S,7S)-hydrobenzosydowic acid (2), and (7 R,10R)-11-dehydroxy-iso-10-hydroxysydowic acid (3), along with the known analogues (S)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (4) and trihydroxybutyl ester of 4-carboxydiorcinol (5) were isolated from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007. Their structures were determined by spectroscopic analysis. Compound 4 with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of 1-5 and cytotoxicity of 1-3 were also evaluated.

Source: Journal of Asian Natural Products Research

DOI: 10.1080/10286020.2024.2443086

Authors: Xu-Meng Ren, Ke-Yue Wu, Shu-Hua Qi

Institutions: Chinese Academy of Sciences, South China Sea Institute Of Oceanology, University of Chinese Academy of Sciences

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W4405860368

FWCI: 0.478

Cites: 15

Cited by: 2

Related to: 10