Efficacy of a hydrogen–oxygen generator in treating cigarette smoke–induced chronic obstructive pulmonary disease in rats
Year: 2024
Type: article
Abstract: • Our findings indicate successful establishment of a rat model of CS–induced COPD. • The hydrogen–oxygen generator outperformed steroid treatment in conferring the recovery benefit for CS–induced COPD rats. • TAPSE helps detect potential damage to the right ventricular function in patients with COPD. Current treatments for chronic obstructive pulmonary disease (COPD), a common respiratory condition, include oxygen therapy and steroids for temporary relief. In this study, we established a rat model of cigarette smoke (CS)–induced COPD and investigated the benefits of a hydrogen–oxygen generator in this model. CS–exposed rats were treated using either a hydrogen–oxygen generator or a steroid. A hydrogen–oxygen generator reduced the neutrophil, lymphocyte, and eosinophil counts compared to natural recovery, whereas steroid treatment increased the total white blood cell, neutrophil, lymphocyte, monocyte and eosinophil counts. Furthermore, the mean linear intercept and the mean alveolar number were 59.8%, and 188.3%, respectively, after treatment with the generator, compared to the values observed with natural recovery. Finally, the generator increased the tricuspid annular plane systolic excursion values by 113.1% compared with the values in natural recovery. Our findings indicate successful establishment of a rat model of CS–induced COPD and demonstrate the potential benefits of using a hydrogen–oxygen generator for COPD patients.
Source: Current Research in Toxicology
Authors: Wan-Ting Huang, Tzong-Jih Cheng, Lin-Hsiang Huang, Yung-Te Hou
Institution: National Taiwan University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,170
Award: G3433885755
OpenAlex ID: W4405861849