Automated electrochemical oxygen sensing using a 3D-printed microfluidic lab-on-a-chip system
Year: 2024
Type: article
Abstract: ; a specific ROS). This microfluidic lab-on-a-chip system was fabricated using high-resolution 3D printing technology in a one-step process. It incorporates a micromixer, an on-chip bubble-trap, an electrochemical cell with fabricated gold or platinum black-coated working electrodes as well as an Ag/AgCl reference electrode, and a commercial optical oxygen sensor for validation. This device enables an automated variation of the oxygen levels as well as sensitive electrochemical oxygen monitoring (limit of detection = 11.9 ± 0.3 μM), with a statistically significant correlation with the optical sensor. The proposed system can serve as a tool to characterize and evaluate custom-made electrodes. Indeed, we envision that in the future it will be used to regulate dissolved oxygen levels and oxygen species in real time in organ-on-chip systems.
Source: Lab on a Chip
DOI: 10.1039/d4lc00962b
Authors: Daniel Kaufman, Steffen Winkler, Christopher Heuer, Ahed Shibli, Alexander Snezhko, Gideon I. Livshits, Janina Bahnemann, Hadar Ben-Yoav
Institutions: Ben-Gurion University of the Negev, University of Augsburg
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4405868152