Work

Antigenotoxic Activity of Gracilaria Sp. on Erythrocytes of Nile Tilapia Exposed by Methomyl-based Pesticide

Year: 2024

Type: article

Abstract: This research investigates the biochemical profile, antioxidant properties, and antigenotoxic activity of red seaweed (Gracilaria sp.) extract on micronuclei formation in peripheral blood erythrocytes of tilapia (Oreochromis niloticus) exposed to a methomyl-based pesticide. Results revealed a diverse phytochemical profile in the red seaweed extract, with the presence of alkaloids, triterpenoids, steroids, tannins, coumarins, terpenoids, quinine, phytosteroids, flavonoids, and phlobtannins. GC-MS analysis identified compounds such as Heptadecane, Neophytadine, Hexadecanoic acid, Oleic acid, and Adipic acid in the sample. The antioxidant activity exhibited a concentration-dependent response, demonstrating increased strength with higher extract concentrations. Antigenotoxic analysis indicated a significant reduction in micronuclei frequency in peripheral erythrocytes of tilapia. In conclusion, the research underscores the potential of red seaweed extract as a valuable natural resource with antioxidant properties and a mitigating effect on genotoxicity induced by pesticide exposure in aquatic organisms.

Source: IRAQI JOURNAL OF AGRICULTURAL SCIENCES

DOI: 10.36103/5n7ygp68

Authors: R.A. Islamy, V. Hasan, Sze-Wan Poong, Y. Kilawati, A.P. Basir, A.S. Kamarudin

Institutions: University of Brawijaya, Universitas Airlangga, University of Malaya, Diponegoro University

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $200