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Effects of Low-Intensity Transcranial Magnetic Stimulation in Neuropsychological Development of Pediatric Subjects With Autism Spectrum Disorder: A Longitudinal Retrospective Approach

Year: 2024
Type: article
Study design: Clinical Trial
Abstract: BACKGROUND: Autism spectrum disorder (ASD) is a heterogeneous neurobiological condition characterized by behavioral problems and delayed neurodevelopment. Although transcranial magnetic stimulation (TMS) has been proposed as an alternative treatment for patients with ASD because of its promising benefits in reducing repetitive behaviors and enhancing executive functions, the use of high-intensity pulses (Hi-TMS) appears to be related to the side effects of the therapy. Low-intensity TMS (Li-TMS) has been partially investigated, but it may have clinical effects on ASD and simultaneously increase treatment safety. METHODS: In this study, the effects of combined intervention with Li-TMS and conventional therapies were evaluated in 35 patients from Ecuador (six female and 29 male), aged between three and seven years, with a confirmed diagnosis of ASD. Each subject received conventional therapies twice a week (for four weeks) provided at the research center (psychological, occupational, speech, and neuro-psychomotor therapies) alongside daily Li-TMS sessions at 1 Hz and 9 mT of intensity targeting the left dorsolateral prefrontal cortex (L-DLPFC) for 45 min for four weeks (16 sessions in total). The Battelle Developmental Inventory (BDI), first edition, was applied before and after Li-TMS therapy to evaluate its clinical effects in subjects with ASD. Weekly follow-up assessments and parent questionnaires were administered to identify any adverse events. RESULTS: In all BDI domains, a significant statistical difference was observed between the pre- and post-intervention averages, supported by extremely low p-values (less than 0.001 in all cases). The personal, social, motor, cognitive, and communicative skills of all the study participants increased after Li-TMS therapy. At the same time, the calculated maturational delay had a significant decrease, suggesting an improvement of ~7.78 months in the neurodevelopment of the ASD subjects. However, age was also found to be a possible cause for these changes in development and maturation. No adverse effects were observed. CONCLUSIONS: Both variants of TMS, Hi-TMS and Li-TMS, have proven to be promising treatments for subjects with ASD, improving social and cognitive abilities. This investigation suggests that the combination of conventional therapies and 16 sessions of Li-TMS as a treatment for individuals with ASD had significant clinical progress, specifically in maturation development according to BDI. In addition, the use of low-intensity magnetic fields may allow for safer pulse delivery in pediatric subjects, as no side effects were reported in this study.
Source: Cureus
DOI: 10.7759/cureus.76569
Language: English
Open Access status: diamond
OpenAlex ID: W4405874800
FWCI: 1.179
Cites: 40
Cited by: 5
Related to: 10