Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Introduction: Because it increases the risk of fracture and bone fragility in postmenopausal women, osteoporosis is a serious health problem. It has been suggested that taking vitamin D supplements may help prevent osteoporosis by improving bone mineralization and calcium absorption. Objective: The purpose of this research was to find out how well vitamin D supplementation works to prevent postmenopausal women from developing osteoporosis. Methods: A total of 122 postmenopausal women were randomly assigned to the intervention (n = 61) and control (n = 61) groups after being recruited at Lady Reading Hospital in Peshawar, Pakistan. Daily 2000 IU vitamin D3 supplementation was given to the intervention group, while a placebo was given to the control group. At baseline and a year later, serum vitamin D levels, bone mineral density (BMD), and fracture incidence were measured. Results: After a year, the lumbar spine BMD (0.895 g/cm² to 0.918 g/cm², p < 0.01) and blood vitamin D levels (22.5 ng/mL to 35.8 ng/mL, p < 0.001) significantly increased in the intervention group, but these measures did not significantly alter in the control group. In addition, there were fewer fractures in the intervention group (4 vs. 11 instances, p < 0.05) than in the control group. Conclusion: In postmenopausal women, vitamin D treatment successfully lowers the incidence of fractures, improves BMD, and raises blood vitamin D levels. These results demonstrate the possibility of vitamin D supplementation in this population as a prophylactic against osteoporosis. It is necessary to do further study to examine long-term results and the best supplementation techniques.
Authors: Afiyat Ahmad, Ahmad Khushal, Syed Sikandar Ali Shah, Zia Ul Islam, Asif Bashir, Faisal Aziz
Institution: Khyber Medical College
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405876066