Year: 2024
Type: article
Study design: Systematic Review
Abstract: BACKGROUND: Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes (T2D); however, the underlying mechanisms remain unknown. DNA methylation may play a role in this process. AIM: To identify the genes associated with pesticide exposure and T2D by reviewing the current literature. METHODS: We systematically searched PubMed and Embase for relevant studies that examined the association between pesticide exposure and DNA methylation, and studies on DNA methylation and T2D through January 15, 2024. RESULTS: ) related to pesticide exposure and T2D. We also suggested future research directions to better define the role of DNA methylation in the association between pesticide exposure and T2D. CONCLUSION: DNA methylation of specific genes may play a vital role in the association between pesticide exposure and T2D.
Source: World Journal of Diabetes
Authors: Guang-Jun Zheng, Zheng-Er Fang, Bi-Ying Zhou, Lei Zuo, Xia Chen, Ming-Liang Liu, Lei Yu, Chun-Xia Jing, Guang Hao
Institutions: Jinan University, Guangdong Pharmaceutical University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4405878682