Evaluation of latent-transforming growth factor beta-binding protein, dopamine and serotonin in patients with chronic epilepsy according to disease type and body mass index
Year: 2024
Type: article
Study design: Observational Study
Abstract: The study aimed to evaluate some biochemical, immunological, physiological and neurotransmitter variables in chronic epilepsy patients. The study comprised 60 patients with epilepsy and a control group of 30 healthy persons, aged between 15 and 60 years. The investigation involved quantifying the amounts of dopamine, serotonin, latent-transforming growth factor beta-binding protein 1 (LTBP1), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). The findings of the present investigation indicated the following: A notable reduction (p≤0.01) in the levels of latent transforming growth factor binding proteins (LTBP1) relative to the control group. A notable elevation (p≤0.01) in the levels of dopamine, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) was observed in comparison to the control values. A substantial elevation (p≤0.05) in serotonin levels was observed relative to the control data. This study indicated a reduction in the levels of LTBP1. The concentration of dopamine, serotonin, AST, ALT, and ALP is elevated in patients with persistent epilepsy compared to healthy individuals.
Source: Wasit Journal of Pure sciences
DOI: 10.31185/wjps.558
Author: Saba Dhamin shakir
Institution: University of Tikrit
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405881093