Year: 2024
Type: article
Abstract: In recent years, there has been significant advancement in the creation of microfluidic devices for sorting circulating tumor cells (CTCs), which has transformed the field of cancer diagnosis. This study offers a thorough examination of the most recent developments in microfluidic technology created for accurate and effective isolation of CTCs from intricate biological materials. The integration of active and passive techniques on microfluidic systems has resulted in advancements in sensitivity, specificity, and therapeutic relevance. Advanced methods like acoustofluidic and microfluidic dielectrophoresis can be used for specific capture of circulating tumor cells (CTCs), while simpler approaches such as size-based filtering and deterministic lateral displacement are suitable for various sample types. Hybrid methods, which blend the advantages of active and passive principles, have become a potential strategy for enhancing CTC isolation efficiency. These advancements have far-reaching implications for liquid biopsy applications, making it easier to monitor cancer progression, detect it early, and evaluate responses to treatment without intrusive procedures.
Institution: University of Technology Malaysia
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
Funder: Universiti Teknologi Malaysia
Awards: G1001717021, G6084887513
OpenAlex ID: W4405881141