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BIOAKTIF ALAMI DARI TAPAK DARAH (Catharanthus roseus) TERHADAP PENYAKIT HIPERTENSI DENGAN PENDEKATAN DASAR PENELITIAN IN SILICO

Year: 2024

Type: article

Abstract: Ajmalicine is a natural secondary metabolite compound found in the Catharanthus roseus plant, which has potential as an antihypertensive agent. Docking simulations were used to explore the molecular interactions between Ajmalicine and its identified target protein, the Alpha-2A adrenergic receptor, using three servers: PharmMapper, SwissTargetPrediction, and SuperPred. The analysis was supported by software such as PyMOL and LigPlus, Discovery Studio 2016 Client, and PyRx 0.8. The results showed that Ajmalicine interacts with the target protein, and this interaction was compared with a control compound, Clonidine, a chemical already used as an antihypertensive drug. The findings revealed that Ajmalicine binds to the same site on the target protein as Clonidine.

Source: Biofaal Journal

DOI: 10.30598/biofaal.v5i2pp116-122

Authors: Monalisa Pertiwi Jeriska Taihuttu, Fernando A Watung, Yudrik A Latief

Institutions: Universitas Pattimura, Manado State University

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405883498

FWCI:

Cites: 9

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Related to: 10