Effect of Filtered Coffee on the Liver and Adipose Tissue Fat Accumulation in Rats on a High-Fat Diet
Year: 2024
Type: article
Abstract: This study was designed to investigate if filtered coffee can lower liver and adipose tissue fat accumulation in rats fed a high-fat diet.Male Sprague-Dawley rats were initially fed a standard AIN-93 diet supplemented with 3% lard and 0.2% cholesterol for 4 weeks.Then, they were weight-matched and assigned to the following two groups: 1) Control group: Rats were fed the standard AIN-93G diet alone, and 2) Coffee group: Rats were fed the standard AIN-93G diet mixed with filtered coffee powder.At weeks 4, the liver and visceral fat tissues (epididymal and retroperitoneal fats) were collected and measured.Liver lipids were separated by solid phase extraction into cholesteryl esters, triglycerides, free fatty acids, and phospholipids, and their respective fatty acid compositions were measured.The concentrations of fatty acids in epididymal and retroperitoneal fats were measured.Filtered coffee significantly lowered fat accumulation in the liver and in visceral fats.Fatty acid levels of the hepatic cholesterol esters and triglyceride fractions were reduced by filtered coffee consumption.Also, filtered coffee resulted in significant reductions in the fatty acid levels of epididymal and retroperitoneal fats.Taken together, the results indicate that filtered coffee has an inhibitory effect on fat accumulation in both the liver and visceral fat tissues, suggesting that drinking filtered coffee daily can be useful as a dietary anti-obesity means.
Authors: Juyeon Kim, SoYoon Ju, Sang Kyu Noh
Institution: Changwon National University
Language: English
Topic: Coffee research and impacts
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405885077