Figure 2 from Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression
Year: 2024
Type: other
Abstract: CD83 influences tumor growth in the pB-IUE system. Kaplan–Meier survival curve of pB-IUE tumors control (n = 17, Med OS = 102 days), CD83KO (n = 20, Med OS = 94 days), and CD83OE (n = 16, Med OS = 116 days; log-rank, all three curves, P value = 0.018; A). Age-matched P60 brains demonstrating decreased growth of CD83OE tumors compared with control and CD83KO tumors (B). Hematoxylin and eosin stain of pB-IUE control, CD83OE, and CD83KO tumors (C and D). IHC for Ki67 of pB-IUE control, CD83OE, and CD83KO tumors (one-way ANOVA P value = 0.0133. Tukey MCT: CD83KO vs. CD83OEP value = 0.0158, CD83KO vs. control P value = 0.8075, and CD83OE vs. control P value = 0.0454; E and F). EdU staining of in vitro cultured control, CD83OE, and CD83KO tumors (one-way ANOVA P value < 0.0001. Tukey MCT: CD83KO vs. CD83OEP value = 0.0193, CD83KO vs. control P value < 0.0001, and CD83OE vs. control P value < 0.0001; G and H). *, P value < 0.05; ****, P value < 0.0001. (Created with Biorender.com.)
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4405886543