Figure 1 from Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression
Year: 2024
Type: other
Abstract: Antigen presenting–like tumor cells express Cd83 in human and mouse glioma. Expression of GO:0002291: T-cell activation via T-cell receptor contact with antigen bound to MHC molecule on APC and GO:0002468: dendritic cell antigen processing and presentation in human IDHWT and IDHmut glioma tumor cells that were differentially expressed (A). scRNA-seq from five IDHmut and seven IDHWT gliomas demonstrate a rare population of CD83+ tumor cells (B and C). Percentage of IDHmut and IDHWT tumor cells from scRNA-seq that expressed different combinations of CD45 and CD83 (D). Immunofluorescence imaging for IDH1R132H tumor cells that express CD83 (E). scRNA-seq from pB-IUE glioma isolates similar murine tumor cells (F). Percentage of murine tumor cells from scRNA-seq that expressed different combinations of CD45 and CD83 (G). Multispectral flow cytometry isolates a distinct population of GFP+CD83+ tumor cells (H). (Created with Biorender.com.)
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4405886544