Figure 3 from Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression
Year: 2024
Type: other
Abstract: CD83 gene signature related to tumor survival, reduced immunosuppressive response signatures, and enhanced antitumor response gene signatures. Expression of CD83 in scRNA-seq from pB-IUE CD83OE compared with control pB-IUE tumors (A). EnrichR analysis of the identified DEGs enriched in CD83+ tumor cells (B). Kaplan–Meier survival of TCGA IDHWT GBM of tumors with high CD83 gene scoring compared with low CD83 gene scoring (median = 19.9 months vs. 12.9 months, P value = 0.027; C). Kaplan–Meier survival of IDHmut low-grade gliomas with high CD83 gene scoring compared with low CD83 gene scoring (median OS = 202.8 months vs. 84.7 months, P value = 0.0022; D). Heatmap of CD83 gene scoring and immune expression gene profiles (E). Immunosuppressive gene sets vs. CD83 gene score showing an inverse relationship between CD83 signature and regulatory T cell (R = −0.65; P = 0.0034), TAM (R = −0.79; P = 0.00011), and PD-1–PD-L1 (R = −0.73; P = 0.00053) gene signatures in our 12 human glioma single-cell samples (F). Antitumor response gene sets vs. CD83 gene score showing a direct relationship between CD83 signature and CD8 T cell (R = 0.58; P = 0.012), central memory T cell (R = 0.57; P = 0.013), and Th cell (R = 0.45; P = 0.064) gene signatures in our 12 human glioma single-cell samples (G). *, P value < 0.05; **, P value < 0.01. (Created with Biorender.com.)
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4405886593