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Do thyroid hormones determine the neurotoxicity of cadmium?

Year: 2024

Type: article

Abstract: Α recent experimental study on rats has shown that the neurotoxicity of cadmium (Cd) could be associated with the levels of thyroid hormones. We, herein, discuss these findings and focus on the effects of the exposure to Cd on a widely-employed neurotoxicity marker: the activity of brain acetylcholinesterase (AChE). Moreover, we assess the novelty of the association between Cd-induced neurotoxicity and the levels of thyroid hormones, reflect on the poor understanding of the nature and the mechanisms defining the interplay between Cd and thyroid function, and highlight the complexity of achieving reliable and comparable experimental assessments of Cd-induced neurotoxicity through the employment of AChE activity as a marker. Finally, we express the opinion that the systematic co-assessment of the levels of thyroid hormones as well as their pharmacological manipulation could prove to be very useful in the elucidation of the mechanisms underlying Cd-induced neurotoxicity.

Source: Epitheorese Klinikes Farmakologias kai Farmakokinetikes – Greek Edition

DOI: 10.61873/ocug6638

Authors: Apostolos Zarros, Hussam W. Al-Humadi, Christina Elliott

Language: English

Topic: Heavy Metal Exposure and Toxicity

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4405886994

FWCI:

Cites: 8

Cited by:

Related to: 10