Work

Chlorinated Phenolic, Benzenoid, and Phenylethanoid Glucosides From the Mangrove Endophytic Fungus Fuscoporia sp. A2A6

Year: 2024

Type: article

Abstract: ABSTRACT A total of 12 new compounds, named fuscoposides A–L ( 1–12 ), including 2 phenolic, 9 benzenoid, and 1 phenylethanoid glucosides, were isolated from the mangrove endophytic fungus Fuscoporia sp. A2A6. The structures of these compounds were established by HRESIMS, NMR spectroscopic data, single‐crystal x‐ray diffraction analysis, and chemical methods. Most notably, 10 compounds, namely, fuscoposides A–I ( 1–9 ) and fuscoposide L ( 12 ), are mono‐ or di‐chlorinated. Fuscoposide C ( 3 ) exhibited moderate neuroprotective effects against H 2 O 2 ‐induced oxidative damage in mouse hippocampal neuron HT‐22 cells in a dose‐dependent manner at the concentration range of 2.0–6.0 µM, whereas fuscoposide G ( 7 ) decreased the expression of COX2 in lipopolysaccharide‐stimulated mouse microglia BV2 cells at the concentration of 5.0 µM, thereby displaying anti‐inflammatory activity.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202403196