Work

Linezolid-Induced Lactic Acidosis: A Case Report

Year: 2024

Type: article

Abstract: Linezolid, an oxazolidinone antibiotic, is widely used to treat infections caused by gram-positive bacteria that are resistant to other antibiotics. It inhibits bacterial protein synthesis by targeting rRNA. Although generally safe when used for short durations in uncomplicated patients, prolonged use may lead to adverse effects. Here, we present the case of a 66-year-old female with a complex orthopedic history, who developed a prosthetic knee infection unresponsive to other antibiotics. Consequently, she was treated with an extended course of linezolid therapy, which resulted in the development of lactic acidosis despite normal liver and kidney function.

Source: Cureus

DOI: 10.7759/cureus.76618

Authors: Moiuz Chaudhri, Eric Costanzo, Nusha Fareen, Mayurkumar Patel

Institutions: Hackensack Meridian Health, Jersey Shore University Medical Center

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405890973