Work

Exploring the Therapeutic Potentials and Molecular Mechanisms of Coscinium fenestratum Alkaloids in Ulcerative Colitis: An Integrative Network Pharmacology and Molecular Docking Approach

Year: 2024

Type: article

Abstract: , which were functionally involved in the immunological response, tumor necrosis factor signaling pathway, and interleukin-17 signaling pathway. The molecular docking results indicated that CFA compounds had a strong binding affinity for the hub genes. The findings reveal, for the first time, a therapeutic role of CFA in alleviating ulcerative colitis through its predicted interactions with relevant biological targets.

Source: Preventive Nutrition and Food Science

DOI: 10.3746/pnf.2024.29.4.441

Authors: Ji-Won Park, Razanamanana H.G. Rarison, Van-Long Truong, Woo-Sik Jeong

Institution: Kyungpook National University

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Research Foundation of Korea, Ministry of Science and ICT, South Korea