Work

Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants

Year: 2024

Type: article

Abstract: -2P. In addition, boosting with a specific vaccine has the potential to remodel the existing immune profiles. These findings indicated that adenovirus-vectored vaccines and mRNA vaccines would be more effective than other types of vaccines as booster shots in combating Omicron infections. Moreover, the protective efficacies of the vaccines in booster vaccinations are highly related to GC reactions in secondary lymphatic organs. In summary, these findings provide timely important information on prime-boost regimens and future vaccine design.

Source: Acta Pharmaceutica Sinica B

DOI: 10.1016/j.apsb.2024.12.030

Authors: Yi Wu, Xiaoying Jia, Namei Wu, Xinghai Zhang, Yan Wu, Yang Liu, Minmin Zhou, Yanqiong Shen, Entao Li, Wei Wang, Jiaming Lan, Yucai Wang, Sandra Chiu

Institutions: University of Science and Technology of China, Chinese Academy of Sciences, Wuhan Institute of Virology, State Key Laboratory of Virology, University of Chinese Academy of Sciences

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,600

Funders: Natural Science Foundation of Shanghai, National Natural Science Foundation of China, Chinese Academy of Sciences, University of Science and Technology of China, National Key Research and Development Program of China

Awards: 基于冠状病毒核蛋白的血清学检测方法研究与应用, G223458808, G228899450, G2344133380, G4690663813, G6051074544, G6984139610, G8127811536, G8350602110

OpenAlex ID: W4405893502

FWCI: 0.63

Cites: 57

Cited by: 2

Related to: 10