Work

Discovery of a Natural Ent-Kaurene Diterpenoid Oridonin as an E3 Ligase Recruiter for PROTACs

Year: 2024

Type: article

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.4c14650

Authors: Jie Huang, Xuekun Fu, Fang Qiu, Zhijian Liang, Chunhao Cao, Zhuqian Wang, Hongzhen Chen, Siran Yue, Duoli Xie, Yiying Liang, Aiping Lu, Chao Liang

Institutions: Hong Kong Baptist University, Southern University of Science and Technology, Shanghai University of Traditional Chinese Medicine, State Key Laboratory of Proteomics

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Research Grants Council, University Grants Committee, Science, Technology and Innovation Commission of Shenzhen Municipality, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1406042316, G1753612344, G371944149, G4776882740, G5748669251, G5843463501, G5954605393, Development of combination therapy using a mCRP aptamer and Leflunomide for precision medicine-based rheumatoid arthritis treatment, G7314405616

OpenAlex ID: W4405894571

FWCI: 3.003

Cites: 93

Cited by: 26

Related to: 10