Work

A Novel Dendrobine‐Derived Phase‐Transfer Catalyst

Year: 2024

Type: article

Abstract: The development of novel and efficient chiral catalysts has always been a focus of research in the field of organic synthesis. In this paper, we present the design, synthesis, and application of a new chiral phase‐transfer catalyst derived from Dendrobine alkaloid using simple synthetic methods with competitive yields. Meanwhile, the unique chiral skeleton structure of our catalyst was conducive to chiral induction in asymmetric catalysis and has been successfully utilized in the asymmetric alkylation of β ‐keto esters, leading to excellent reactivity and good enantioselectivity in the formation of chiral 1H‐inden‐1‐ones.

Source: ChemistrySelect

DOI: 10.1002/slct.202405664

Authors: Xiaojiang Shen, Yijun Liu, Shuo Chen, Fawu Dong, Jiangmiao Hu, Shulin Ge

Institutions: Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan University of Traditional Chinese Medicine, Yunnan Agricultural University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Natural Science Foundation of China

Awards: G1725322036, G8956136352