In vitro Antiproliferative Activity of Lissotriton schmidtleri (Raxworthy, 1988) Skin Secretion on Human Breast Cancer (MCF7) Cell Line
Year: 2024
Type: article
Abstract: : In this study, the in vitro antiproliferative activity of Lissotriton schmidtleri skin secretion on estrogen-sensitive human breast cancer (MCF7) cells was reported for the first time. The effects of L. schmidtleri skin secretion at concentrations of 0.5, 5, and 50 μg/mL on the MCF7 cell line were evaluated using the MTT assay after 48 hours of incubation. According to the MTT assay results, L. schmidtleri skin secretion inhibited MCF7 cell viability by approximately 64% at a concentration of 50 μg/mL, with an IC50 value calculated as 20.81 ± 0.87 μg/mL. Based on these findings, it is suggested that L. schmidtleri skin secretion may serve as a potential anticancer agent against breast cancer.
Source: Commagene Journal of Biology
Author: Mert Karış
Institution: Nevşehir Hacı Bektaş Veli University
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
Funder: Ege Üniversitesi
OpenAlex ID: W4405899199