Eastern Cooperative Oncology Group Performance in Malaysian Oral Cavity Carcinoma: Treatment, Demographics and Clinical Factors
Year: 2024
Type: article
Study design: Observational Study
Abstract: Eastern Cooperative Oncology Group (ECOG) is gaining importance as a valuable outcome measure in the field of oral cavity carcinoma (OCC). This study aimed to assess pre- and post-treatment ECOG changes in Malaysian OCC patients undergoing various treatments. We conducted a 12–36 months longitudinal observational study with 63 squamous cell carcinoma patients, evaluating ECOG perfomance, medical history, symptoms, sociodemographics, clinical details, and treatment modalities (surgery, surgery + radiotherapy, or surgery + chemotherapy and radiotherapy [CCRT]). OCC patients aged 50–70 years are at risk for impaired quality of life (QOL) up to several years after diagnosis. The analysis of the association between baseline ECOG Performance Status (ECOG-PS) scores and demographic data revealed a statistically significant correlation only within the age group, demonstrating a p-value of 0.031. CCRT treatment has a more pronounced effect on patient performance status, with significant results in the 3-year overall survival rate and poor ECOG-PS score in patients post-CCRT, as well as radiotherapy. These results highlight the need to provide OCC patients with specialised interventions and support, especially while they are undergoing CCRT, to lessen the potential negative effects on their general well-being and quality of life.
Source: Archives of Orofacial Sciences
Authors: Kelvinder Singh, Atiqah Aziz, MohdZukiflee Abu Bakar, Prepageran Narayanan
Institution: University of Malaya
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405900927