Year: 2024
Type: article
Study design: Observational Study
Abstract: This study aimed to calculate Italy's first national maternal mortality ratio (MMR) through an innovative record-linkage approach within the enhanced Italian Obstetric Surveillance System (ItOSS). A record-linkage retrospective cohort study was conducted nationwide, encompassing all women aged 11-59 years with one or more hospitalizations related to pregnancy or pregnancy outcomes from 2011 to 2019. Maternal deaths were identified by integrating data from the Death Registry and national and regional Hospital Discharge Databases supported by the integration of findings from confidential enquiries conducted through active surveillance. Maternal Mortality Ratio (MMR), direct MMR (DMMR), and causes of maternal death are the study main outcomes. The MMR was found to be 8.4 per 100,000 live births (95% CI 7.5-9.3), significantly higher than the 3.9 per 100,000 (95% CI 3.3-4.5) calculated solely from the Death Registry, with a notable declining trend over the study period. Causes of death have been classified according to the 10th International Classification of Diseases. Within 42 days from pregnancy outcome, leading causes were obstetric haemorrhage, sepsis, and cardiovascular diseases. Late maternal deaths were primarily attributed to suicide, malignancies, and cardiovascular diseases. This integrated methodology provides a comprehensive understanding of maternal mortality trends and causes in Italy, offering valuable insights for countries utilizing or planning enhanced surveillance systems.
Source: Scientific Reports
Authors: Alice Maraschini, Donatella Mandolini, Ilaria Lega, Paola D’Aloja, Edoardo Corsi Decenti, Giovanni Baglio, Giada Minelli, Serena Donati, ItOSS Regional Working Group, Antonello Antonelli, Sergio Battaglia, Gabriella Dardanoni, Valentina Domeneghetti, Michele Ercolanoni, Eliana Ferroni, Barbara Gamboni, Manuela Giangreco, Roberta Giordana, Anna Maria Nannavecchia, Eva Papa, Riccardo Pertile, Arianna Polo, Marco Pompili, Monia Puglia, Raffaella Rusciani
Institutions: Istituto Superiore di Sanità, Regione Autonoma della Sardegna, Regione Siciliana, Regione Autonoma Valle d'Aosta, Regione Lombardia, Regione del Veneto, Regione Umbria, IRCCS Materno Infantile Burlo Garofolo, Regione Campania, Agenzia Regionale Sanitaria della Puglia, Provincia autonoma di Bolzano - Alto Adige, Azienda Sanitaria dell'Alto Adige, Provincia Autonoma di Trento, Regione Lazio, Regione Marche, Agenzia Regionale di Sanità della Toscana
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funder: Ministero della Salute
OpenAlex ID: W4405909565