Work

Generation of an induced pluripotent stem cell line from a Kennedy Disease patient with AR mutation

Year: 2024

Type: article

Abstract: A human induced pluripotent stem cell (iPSC) line was generated from patient with Kennedy Disease (KD), who carried the CAG repeat expansion mutation in AR gene. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using non-integrating delivery of KFL4, OCT4, SOX2, BCL-XL and c-MYC. The iPSC line expresses pluripotency markers, displays a normal karyotype, and is capable of differentiate into three germ layers in vitro. This iPSC line represents a valuable cell model for studing KD in humans.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2024.103649

Authors: Meng Zhang, Rui Liu, Pengpeng Sun, Chengsen Zhang, Jingdong Wang, Changjiang Li

Institution: University of Health and Rehabilitation Sciences

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,320