Work

A Case of Canine Sinonasal Aspergillus fumigatus Infection Associated With Intracranial Extension and Temporal Myositis

Year: 2024

Type: article

Abstract: A 12-year-old terrier was referred for investigation of a 4-month history of coughing, sneezing and nasal discharge. Clinical findings were consistent with sinonasal Aspergillus fumigatus infection with evidence of intracranial extension on computed tomography. Endoscopic debridement followed by topical clotrimazole and systemic antifungal therapy resulted in clinical improvement. Magnetic resonance imaging after 4 weeks showed reduced intracranial disease but demonstrated evidence of temporal myositis. Repeated debridement and topical treatment were performed at 4 and 8 weeks in conjunction with long-term voriconazole therapy. Further interventions were declined; the dog remains clinically well after 4 months with unilateral nasal discharge. As in human patients, invasive subtypes of sinonasal aspergillosis may also occur in dogs and be associated with poorer response to treatment.

Source: Veterinary Medicine and Science

DOI: 10.1002/vms3.70188

Authors: Sarah E. Cox, Giulia Cattaneo, Oliver Russell, Ombeline McGregor, Andre Kortum

Institution: University of Cambridge

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,700