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Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report

Year: 2024

Type: article

Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disorder with both articular and extra-articular manifestations, including rare pulmonary complications. We report a case of a 65-year-old male with long-standing RA who developed multiple cavitary pulmonary nodules following prolonged leflunomide therapy. Diagnostic evaluation excluded infectious, neoplastic, and autoimmune causes. Bronchoscopy and biopsy confirmed an acute suppurative inflammatory process with central necrosis. Discontinuation of leflunomide resulted in the resolution of pulmonary nodules. This case highlights the need for vigilance regarding potential pulmonary toxicity in RA patients receiving leflunomide and underscores the importance of prompt recognition and management of drug-induced complications.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.9615

Authors: Mahdiye Abiyarghamsari, Arman Ahmadzadeh

Institutions: Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,730