Work

Tumor cells ectopically expressing the membrane-bound form of IL-7 develop an antitumor immune response efficiently in a colon carcinoma model

Year: 2024

Type: article

Abstract: T cells, and dendritic cells in tumors formed by the mbIL-7/B7 clone compared to those formed by the sIL-7 clone. These findings suggest that the membrane-bound form of IL-7 with B7.1 is more effective than the secretory form in establishing antitumor immunity within the tumor microenvironment. Our strategy of expressing the mbIL-7/B7 chimera holds promise as a novel approach for tumor therapy, particularly in cases requiring IL-7 supplementation.

Source: Molecules and Cells

DOI: 10.1016/j.mocell.2024.100175

Authors: Hee-Su Shin, Hyejin Kim, Soon-Gyu Kwon, Hayyoung Lee, Jie-Oh Lee, Young Sang Kim

Institutions: Chungnam National University, Pohang University of Science and Technology

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500