Work

Synthesis and antimicrobial evaluation of 2-thioxoimidazolidinone derivatives

Year: 2024

Type: article

Abstract: The infectious diseases caused by antimicrobial pathogens are often difficult to treat and thwarted by resistance to drugs. Therefore, designing new drugs to treat antimicrobial infections is a challenge in drug discovery research. A series of 2-thioxoimidazolidinone derivatives were synthesized in high yield from N'-arylideneamino-2-thioxoimidazolidin-4-ones using propionyl chloride and triethyl amine in toluene medium. The compounds were screened for the in vitro antifungal and antibacterial activities. The studies revealed that compounds (±)1,1'-(3-(((1E,2E)-3-(2-methoxyphenyl)allylidene)amino)-4-oxo-2-thioxoimidazolidine-1,5-diyl)-bis(propan-1-one) and (±)1,1'-(3-((2,4-dichlorobenzylidene)amino)-4-oxo-2-thioxoimidazolidine-1,5-diyl)bis-(propan-1-one) possess antifungal properties comparable to the reference drug ketoconazole. This study highlights the importance of substituted 2-thioxoimidazolidinone derivatives, and their potential as antimicrobial agents.

Source: Organic Communications

DOI: 10.25135/acg.oc.174.21.3340

Authors: Aiyagala M.M. Mallikarjunasawamy, Praveen Naik, Momidi Bharath Kumar, Kuruvalli Gouthami, Vaddi Damodara Reddy, Vipin A. Nair

Institutions: REVA University, Nitte Meenakshi Institute of Technology, Amrita Vishwa Vidyapeetham

Language: English

Topic: Synthesis and Reactions of Organic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Council of Scientific and Industrial Research, India, Human Resource Development Group, Division of Human Resource Development