Year: 2024
Type: article
Abstract: The escalating prevalence of diabetes mellitus on a global scale has spurred an urgent need for innovative and effective therapeutic interventions, Nelumbo nucifera, commonly known as the sacred lotus, has been revered for centuries in various cultures for its symbolic significance and aesthetic appeal.Beyond its cultural importance, various parts of the Nelumbo nucifera plant, including its seeds, leaves, and rhizomes, are rich repositories of bioactive compounds.These compounds, ranging from alkaloids and flavonoids to polysaccharides, exhibit diverse pharmacological activities and its been a subject of interest for researchers due to their rich phytochemical composition.Among its various bioactive properties, the alpha-glucosidase and amylase inhibition capabilities stand out for their potential in managing diabetes mellitus.These enzymes play crucial roles in carbohydrate metabolism, and their inhibition can effectively control postprandial hyperglycemia, a critical aspect of diabetes management This study is done using different concentrations of samples and standard drugs showing amylase and alpha-glucosidase inhibition properties and analysed and calculated using percentage inhibition formula and it showed the percentage of alpha amylase inhibition by standard concentration 400ug is 53.3 % and sample 500ug is 50%, The percentage inhibition of concentration alpha glucosidase inhibition for standard concentration 400ug is 72.2% and sample 500ug is 71.4%.The study concluded that Nelumbo nucifera possesses both alpha-glucosidase and amylase inhibition properties and is a good natural source of remedy for diabetes, that can be combined with other drugs.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4405919951