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Characterization and Biomedical Applications of Electrospun PHBV Scaffolds Derived from Organic Residues

Year: 2024

Type: article

Abstract: -3-hydroxyvalerate) (PHBV) synthesized from organic residues, specifically milk and molasses. Six PHBV samples with varying 3-hydroxyvalerate (3HV) content (7%, 15%, and 32%) were analyzed to assess how 3HV composition influences their properties. Comprehensive characterization techniques, including NMR, FTIR, XRD, DSC, TGA, and tensile-stress test, were used to evaluate the molecular structure, thermal properties, crystalline structure, and mechanical behavior. Selected PHBV samples were fabricated into nanofibrous scaffolds via electrospinning, with uniform fibers successfully produced after parameter optimization. The electrospun scaffolds were further analyzed using DSC, GPC, and SEM. Biological evaluations, including cytotoxicity, in vitro drug release, and antibacterial activity tests, were also conducted. The results indicate that the electrospun PHBV scaffolds are biocompatible and exhibit promising properties for biomedical applications such as tissue engineering and drug delivery. This study demonstrates the potential of using organic residues to produce high-value biopolymers with tailored properties for specific applications.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms26010180

Authors: Anyi Jin, Germán Pérez, Antxon Martínez de Ilarduya, Luis J. del Valle, Jordi Puiggalí

Institution: Universitat Politècnica de Catalunya

Language: English

Topic: biodegradable polymer synthesis and properties

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: gold

Estimated APC paid: $3,296