Work

Rearranged and enantiomeric alkaloids from Cephalotaxus sinensis

Year: 2024

Type: article

Abstract: Three undescribed alkaloids (1-3) along with 30 known ones were isolated from the twigs and leaves of Cephalotaxus sinensis. The structures of the new alkaloids were determined through comprehensive spectroscopic analysis and ECD calculations. Cephalosinine A (1) with 6/6/6/5 ring system represents a new type of Cephalotaxus alkaloid, which might be formed through a rearrangement from simultaneously isolated cephalotaxinone. Cephalolancine B (2) was the second cephalolancine skeleton alkaloid. (+)-Acetylcephalotaxine α-N-oxide (3) was an enantiomeric Cephalotaxus alkaloid. The isolated homoerythrina-type alkaloids were evaluated for their in vitro hearing protective effects against neomycin-induced cell death in HEI-OC-1 cells.

Source: Tetrahedron Letters

DOI: 10.1016/j.tetlet.2024.155437

Authors: Jing Wu, Xin-Yu Liu, Mei-Fen Bao, Bao-Bao Shi, Ming-Xiang Li, Xiang-Hai Cai

Institutions: Kunming Institute of Botany, Chinese Academy of Sciences, Shenyang Pharmaceutical University, South Central Minzu University

Language: English

Topic: Chemical synthesis and alkaloids

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,690

OpenAlex ID: W4405925651

FWCI: 0.419

Cites: 32

Cited by: 3

Related to: 10