Polyherbal Formulation Development for Parkinson's Disease: Comprehensive Quality Control and Toxicological Evaluation
Year: 2024
Type: article
Abstract: Background and objectives: In this study, extracts from eight herbal medicines Withania somnifera, Nardostachys jatamansi, Convolvulus pluricaulis, Mucuna pruriens, Centella asiatica, Bacopa monnieri, Tinospora cordifolia, and Ginkgo biloba were combined to create a potential medication. Methods: Quality Control study had been done according guideline or procedure drafted by CCRAS, Ministry of AYUSH, Govt. of India, Oral Acute and Repeated Dose 28-day Toxicity Study had been done according to OECD 423 and 407 guidelines. Results: The polyherbal formulation's physiochemical characteristics, phytochemical content, safety profile, and possible impacts on physiological parameters were all carefully assessed. The formulation was establish to be safe at a single administration dose of 2000 mg/kg and safe at repeated doses up to 1000 mg/kg over the course of 28 days. Conclusion: This study highlights the polyherbal formulation's potential for therapeutic application in the cure of Parkinson's disease by offering insightful information on its toxicological properties and quality control.
Authors: Gaurav Sharma, Tejpal Yadav, Sanjeev Sharma, Vikram Kumar
Institutions: National Institute of Ayurveda, Amity University Jaipur
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4405926202