Year: 2024
Type: article
Abstract: A simple synthetic method for pinocembrin from cinnamic acid and 1,3,5-trihydroxybenzene was provided. This method can be performed in one-pot two steps reaction using inexpensive chemical reagents, whereas conventional methods need multiple steps from somewhat expensive starting reagents. The experimental procedure is facilitated, that is, to a DMF solution of cinnamoyl chloride generated in situ, a solution of 1,3,5-trihydroxybenzene and AlCl 3 in DCE/PhNO 2 was added, and the resultant mixture was heated to afford pinocembrin. This method does not require protection of phenolic hydroxy groups.
Source: Journal of Oleo Science
DOI: 10.5650/jos.ess24245
Authors: Kento Iwai, Nagatoshi Nishiwaki
Institutions: Kochi University of Technology, Nara Women's University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $301
OpenAlex ID: W4405929582