Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Ultraviolet (UV) exposure causes direct and indirect damages to skin structures.Human adipose stem cell-conditioned medium (hASC-CM) is a collection of several soluble factors, such as cytokines, chemokines, and Growth Factors (GF), secreted by almost all living cells in the extracellular space which support wound healing and skin rejuvenation.Objective: To determine the effects of human adipose stem cell-conditioned medium (hASC-CM) in photoaged skin and evaluate photoaging improvement after treatment.Methods: An experimental randomized controlled trial was performed, involving 64 photoaged subjects at the Dermato-Venereology Outpatient Clinic of Jemursari Islamic Hospital Surabaya from March to June 2022.The subjects were divided into the hASC-CM group and vehiculum (control) group.Patients' transepidermal water loss value, skin tone, and Glogau score in weeks 0, 4, and 8 were evaluated.The data were then analyzed using Mann-Whitney test (p<0.05).Results: All subjects had Glogau scale of III (89.6%) with mean ± SD (3.121 ± 0.329).hASC-CM group showed higher improvements in the pore, wrinkle, spot polarized, spot UV parameters and skin tone compared to vehiculum group(p<0.05).Conclusions: hASC-CM effectively improved all parameters observed.The limitation of this research was on the lack of long-term followup after treatment.This research had received an ethical permit from The Ethical Committee Board of Jemursari Islamic Hospital Surabaya under letter 006/KEPK-RSISJS/II/2022.aging both in-vitro and in-vivo [6] which can reduce cell death in apoptosis, increase the expression of type I collagen protein and decrease the expression of MMP-1 protein in in-vitro studies [12] .Another in vitro research reported that ASC-CM could downregulate the activation of MAPK signaling pathways and proinflammatory target proteins such as IL-6, inhibit AP-1 activation as well as increasing TGF-β [13] .Adipose stem cell conditioned medium improves the skin barrier through decreased TEWL and increased skin hydration [6,9,14,15] .This research was performed to examine the effects of human adipose stem cell-conditioned medium (hASC-CM) on photoaged skin using Tewameter, skin analyzer device, and Glogau score. Material and methods Research design and participantsIn this experimental randomized controlled trial research, 64 subjects were consecutively selected based on the inclusion criteria.The research took place at the Dermato-Venereology Outpatient Clinic of
Institutions: Universitas Nahdlatul Ulama Surabaya, Universitas Airlangga
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $380
OpenAlex ID: W4405931869