Work

K + currents in ventricular cardiomyocytes of p.N98S-calmodulin mutant mice

Year: 2024

Type: article

Abstract: Despite in vitro and in silico evidence implicating cardiac K + channel dysregulation in LQTS associated with missense mutations in genes-encoding calmodulin, their effects on native cardiac K + currents are unknown. Using a knock-in mouse model harboring the p.N98S mutation in the Calm1 gene, we found no evidence for dysregulation of major cardiac K + channels. Although these data do not support mechanistic findings from heterologous systems, our finding impacts efforts to improve therapies for calmodulinopathies.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00470.2024

Authors: Shuai Guo, Andy Hudmon, Firoj K. Sahoo, Madeline R. Motes, Wen-Chin Tsai, Peng-Sheng Chen, Michael Rubart

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, Purdue University West Lafayette, Cedars-Sinai Medical Center, Cedars-Sinai Smidt Heart Institute

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, Cedars-Sinai Medical Center, National Heart, Lung, and Blood Institute

Awards: G1117859630, G4349661756, Using mirabegron to prevent syncope in patients with postural orthostatic tachycardia syndrome, G7742011501, SK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular Arrhythmogenesis

OpenAlex ID: W4405941480

FWCI: 0.267

Cites: 48

Cited by: 1

Related to: 10