Evaluation of In vitro Antacid Activity of Two Evolvulus Spp. and Formulation of a Novel Drug Delivery System Using the Crude Plant Powder
Year: 2024
Type: article
Abstract: The study investigates the pharmacognosy and in vitro antacid activity of Evolvulus alsinoides (L.) L. and Evolvulus nummularius (L.) L. plant species, that would be used in the formulation of a stable antacid dosage form. Pharmacognostic analyses, phytochemical screenings, and in vitro gastric acid-neutralising activity assay were performed on both of the species. Formulated E. alsinoides chewable granules were subjected to stability assessments under accelerated conditions. E. alsinoides and E. nummularius resulted in more fibres and more crystals in the respective powder samples. Aqueous and ethanolic extracts of both plants produced positive results for common phytochemicals (e.g., flavonoids, alkaloids, phenolics, etc.), but cardiac glycosides were absent in aqueous extracts. Antacid activities of E. alsinoides and E. nummularius were statistically significant (p
Authors: Welipitiya WPWD, Hettiarachchi HUV, HKumara TDMTS, Madushani KHS, Dias NTB, Jayasuriya WJABN, Arawwawala LDAM, Suresh TS
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4405941811