Work

A qualitative structure activity relationship (SAR) study of selected pyroglutamates

Year: 2024

Type: article

Abstract: A library of Pyroglutamate derivatives (Fig. 1-4: 8a-8f, 9a-9d, 10a-10e, 11a-11f, 12a-12c, 13 and 14) have been analysed qualitatively to investigate their Structure Activity Relationships (SAR). Antibacterial screening data used for this work was against the selected multidrug-resistant pathogens including both Gram-negative and Gram-positive bacteria. Among the synthesized compounds, pyroglutamates 8e and 11d are more potent as antibacterial agent. J. Bangladesh Acad. Sci. 48(2); 165-170: December 2024

Source: Journal of Bangladesh Academy of Sciences

DOI: 10.3329/jbas.v48i2.70546

Authors: Halima Bagum, Mark G Moloney, Md Rabiul Islam

Institutions: University of Barishal, University of Oxford, Jahangirnagar University

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: University of Oxford, Commonwealth Scholarship Commission