Work

Diaphragm Ultrasonography in Patients Without Symptoms or Signs of Respiratory Impairment

Year: 2024

Type: article

Abstract: ABSTRACT Introduction/Aims We aimed to determine differences in diaphragm thickness by including/excluding pleural and peritoneal membranes, the variability in diaphragm thickness over the apposition zone, and the predictors of diaphragm thickness and excursion measurements. Methods At least 10 male and female subjects were recruited for each decade of life. Spirometry, respiratory muscle strength, and the diaphragm ultrasound (US) measurements were performed. Multivariate linear regression was applied to determine associations between diaphragm US parameters, subject characteristics, spirometry, and respiratory muscle strength. Results In 156 subjects (mean 47.8 ± 17.7; 20–80 years of age), a significant difference in diaphragm thickness was found when comparing measurements that included and excluded the pleural and peritoneal membranes (mean 2.3 vs. 1.7 mm; average difference of 35% (95% CI [15.3–60]); p < 0.001), as well as the minimum and maximum diaphragm thicknesses at different locations over the apposition zone (mean 1.4 vs. 2.1 mm; p < 0.001). Adjusting for sex, age, height, sniff nasal inspiratory pressure, and forced vital capacity, a positive association was found between body mass index (BMI) and diaphragm thickness (β =0.024, p < 0.001, partial R 2 = 0.31, 95% CI [0.018, 0.030]); a negative association was found with the thickening ratio (β = −0.013, p = 0.050, partial R 2 = 0.04, 95% CI [−0.024, −0.002]). Discussion Caliper placement and the location of measurement over the apposition zone greatly affect diaphragm thickness, which is also associated with BMI. Therefore, a standardized protocol for measuring diaphragmatic thickness and excursion is desirable, and BMI should be considered when interpreting the results.

Source: Muscle & Nerve

DOI: 10.1002/mus.28331

Authors: Martina Gorenc, Rok Blagus, Friderika Kresal, Gregor Omejec

Institutions: University of Primorska, University of Ljubljana, Ljubljana University Medical Centre

Language: English

Topic: Ultrasound in Clinical Applications

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Javna Agencija za Raziskovalno Dejavnost RS