Work

tert-Butyl Hypochlorite: A Reagent for the Synthesis of Chlorinated Oxindole and Indole Derivatives

Year: 2024

Type: article

Abstract: -Butyl hypochlorite was employed as a versatile reagent for chlorooxidation of indoles, chlorination of 2-oxindoles, and decarboxylative chlorination of the indole-2-carboxylic acids. Four types of products including 2-chloro-3-oxindoles, 2,2-dichloro-3-oxindoles, 3,3-dichloro-2-oxindoles, and 2,3-dichloroindoles could be selectively obtained in moderate to excellent yields by switching the substrates. Various synthetically useful functional groups, such as halogen atoms, cyano, nitro, and methoxycarbonyl groups, remain intact during the reactions. Notable features of the approach include the universality of the starting materials, the mild reaction conditions, and the experimental simplicity.

Source: Molecules

DOI: 10.3390/molecules30010102

Authors: Chun-Yan Liu, Xia Chen, Hai-Long Liu, Nan Wang, Xiao-Yu Zhou

Institutions: Dalian University, Liupanshui Normal University

Language: English

Topic: Synthesis of Indole Derivatives

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,069

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guizhou Province, Liupanshui Normal University