Work

Salidroside Could Delays Aging by Regulating the Expression of TERT through Wnt/β-Catenin Pathway

Year: 2024

Type: article

Abstract: This paper attempted to investigate whether salidroside could delay brain hippocampal neuron senescence in mice. Methods The C57/BL6N mice were normally fed to natural aging and then treated with salidroside. The Morris water maze (MWM) test was used to evaluate the behavioral function of mice. HE staining were used to observe neuron damage in the hippocampal tissues of mice. The expression levels of telomerase reverse transcriptase (TERT) were detected by Western blotting. Reslts The results showed that salidroside could improved the cognition of aging mice. Additionally, salidroside improved the pathological changes of hippocampal neurons of aging mice. Western blotting manifested that salidroside could promote the protein expressions of TERT by activating Wnt/β-catenin pathway. Conclusion It is suggestted that salidroside could delay aging of the hippocampal neurons by up-regulating TERT expression through activating Wnt/β-catenin pathway.

Source: American journal of pharmacological sciences

DOI: 10.12691/ajps-13-1-1

Authors: Ke Cai, Xi Yu, Hongbo Li, Jie Zhai, Guanxi Wang

Institutions: Qingdao University, Qingdao Haici Medical Group

Language: English

Topic: Medicinal Plants and Bioactive Compounds

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Qingdao University