FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation
Year: 2024
Type: article
Abstract: Bladder cancer (BC) is a prevalent urinary malignancy and muscle-invasive bladder cancer (MIBC) is particularly aggressive and associated with poor prognosis. One of MIBC features is the nuclear atypia. However, the molecular mechanism underlying MIBC remains unclear. Here, we find that FKBP10 is significantly upregulated in MIBC tissues and correlated with metastasis and poor outcomes. FKBP10 promotes tumor cell invasion, migration, and metastasis, but not proliferation. Notably, FKBP10 enhances the nuclear atypia of BC cells. Mechanistically, FKBP10 interacts with prelamin A and hinder the nuclear entry of prelamin A, thereby leading to the decrease in the nuclear lamin A, a key factor involved in nuclear atypia. In human BC tissues, nuclear lamin A is downregulated and negatively correlated with FKBP10 expression. Overall, our findings demonstrate that the FKBP10/prelamin A/lamin A axis contributes to MIBC.
DOI: 10.7150/ijbs.105265
Authors: Xupeng Zhao, Jichen Wang, Shuo Tian, Lu Tang, Shouqing Cao, Jiali Ye, Tianwei Cai, Yundong Xuan, Xu Zhang, Xiubin Li, Hongzhao Li
Institutions: Nankai University, Chinese PLA General Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4405953735