Work

Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities

Year: 2024

Type: article

Abstract: shows SREBP/SCAP inhibitory activity. The VDR-silent vitamin D analog KK-052 with selective SREBP/SCAP inhibitory activity in vivo was developed. A chemical library of side-chain fluorinated vitamin D analogs is currently under construction, and some analogs have shown potent anti-inflammatory activity and therapeutic effects on psoriasis model mice.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.c24-00598

Author: Atsushi Kittaka

Institution: Teikyo University

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Japan Society for the Promotion of Science