Vulvar keratoacanthoma may be a malignant precursor: A case report and literature review
Year: 2024
Type: article
Study design: Case Report
Abstract: • State why KA is different or difficult to differentiate from other vulvar lesions. • A statement about why surgery is needed to rule out invasive cancer and than it can progress to an invasive cancer. • List whatever most important prognostic factors or clinical managment recommendation. Keratoacanthoma is a relatively rare skin tumor, with vulvar keratoacanthoma being even more uncommon. Although the majority of keratoacanthomas exhibit a benign course, a subset of cases may show features of malignant potential, such as marginal invasion and recurrence. An 82-year-old female presented with a rapidly growing exophytic lesion on the left vulva, measuring 1.5 cm in diameter, accompanied by pruritus. The lesion had been present for two months. The patient underwent vulvar mass excision, and postoperative pathology revealed squamous cell hyperplasia with glassy cytoplasm and no significant cellular atypia. The surgical margins were clear. Three years later, the tumor recurred with disordered growth. In terms of histological and clinical presentation, keratoacanthoma may overlap with classical well-differentiated squamous cell carcinoma. In rare cases, certain atypical keratoacanthomas may exhibit intravascular and perineural invasion, along with lymph node metastasis. By sharing our treatment experience of a patient with recurrent vulvar keratoacanthoma following surgery, we aim to provide a cautionary perspective for the clinical management of such cases.
Source: Gynecologic Oncology Reports
Authors: Fang Chen, Yang Wang, Dina Haishaer, Feng Bai
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $750
OpenAlex ID: W4405954722