Uncommon Association of Primary Biliary Cholangitis and Ulcerative Colitis in a Male Patient, Cirrhosis as a Presenting Feature: A Case Report
Year: 2024
Type: article
Study design: Case Report
Abstract: Primary biliary cholangitis (PBC) is a chronic autoimmune cholangitis characterized by progressive destruction of the small intrahepatic bile ducts, leading to cholestasis and, potentially, liver cirrhosis. While its clinical and biological manifestations are well-documented, its association with inflammatory bowel disease (IBD) remains rare. Inflammatory bowel disease, particularly ulcerative colitis (UC), is frequently linked to hepatobiliary disorders, most notably primary sclerosing cholangitis (PSC). However, the co-occurrence of PBC and UC is highly uncommon and poorly understood. We report a rare case of a male patient in whom PBC and UC coexisted, with cirrhosis being the initial presentation. This case highlights the need for heightened clinical suspicion of atypical hepatobiliary associations in IBD patients and underscores the importance of early recognition and management.
Authors: Semlali R, Handa A, Chakor F, Nacir O, Lairani F, Ait Errami A, Oubaha S, Samlani Z, Krati K
Language: English
Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405957348