Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death
Year: 2024
Type: article
Abstract: The integration of RmPLH with PD-1 inhibitors substantially amplifies ICD, fostering robust antigen-specific T cell immunity and offering a promising therapeutic strategy for TNBC. This study represents a pioneering application of Pt (II)-based LDH nanocages in oncology, laying a foundation for future innovations in tumor immunotherapy.
Source: Theranostics
DOI: 10.7150/thno.102284
Authors: Yanjie Wu, Zhiyu Zhao, Mengli Ma, Weijin Zhang, Wei Liu, Xiaochen Liang, Ting Zhao, Yi Luo, Yunjie Wang, Mengqi Li, Tingting Li, Cong Liu, Xian Luo, Shengyu Wang, Wanyun Li, Wei Zeng, Hong Wang, Wengang Li, Ting Wu, Zhihai Ke, Fanghong Luo
Institutions: Chinese University of Hong Kong, Shenzhen, Duke University, Xiamen University, Guangdong Pharmaceutical University, First Affiliated Hospital of Guangdong Pharmaceutical University, University of California, Riverside, Fujian Medical University, Shandong Provincial Hospital, Shandong First Medical University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4405963354