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Strategies for Constructing Osteosarcoma 3D Culture Models and Progress in Their Applications

Year: 2024

Type: article

Abstract: Osteosarcoma is a highly malignant primary bone tumor, and traditional two-dimensional (2D) culture methods cannot accurately simulate the tumor microenvironment. Three-dimensional (3D) culture better simulates the in vivo tumor microenvironment, providing more realistic experimental data regarding tumor progression, drug resistance, and drug screening. This paper introduces various 3D culture technologies, including scaffold-free culture, scaffold-based culture, microfluidic chips, and bioprinting. Moreover, 3D models show significant advantages in tumor microenvironment simulation, drug screening, and research on osteoblasts and osteoclasts, thus promoting the development of personalized therapy. Overall, 3D culture offers an important tool and platform for a deeper understanding of osteosarcoma's biological mechanisms and improving clinical treatment outcomes.

Source: International Journal of Biology and Life Sciences

DOI: 10.54097/h5e7p918

Authors: Changshuai Qin, Na Huang, Chengyi Qin, Cheng Huang, Zonghui Qiu, Jinheng Wang, Wei Fu, Wusong Liu, Wei Peng, Changgong Lan

Institutions: Youjiang Medical College for Nationalities, Guangxi University of Chinese Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405971279

FWCI:

Cites: 32

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Related to: 10