Perfusion Ct in the Evaluation of Neck Masses
Year: 2024
Type: article
Study design: Observational Study
Abstract: Neck cancer is among the most prevalent carcinomas globally, with squamous cell carcinoma being the predominant type. Two-thirds of cases are diagnosed at advanced stages, making early detection critical to provide optimal treatment. Angiogenesis is pivotal in cancer growth/metastases and is typically assessed through invasive microvascular density (MVD) evaluation which is an invasive procedure with limitation in routine use. This study investigates the role of perfusion CT in characterizing neck masses by correlating perfusion parameters with histopathological ndings. A prospective study was conducted on 30 patients with neck masses. Perfusion parameters—blood ow (BF), blood volume (BV), mean transit time (MTT), and permeability surface area product (PMB)—were quantied and compared with biopsy or surgical specimen results. Results showed that malignant lesions exhibited signicantly higher BF, BV, and PMB, and shorter MTT compared to benign lesions, aiding in differentiation. The study underscores the clinical relevance of perfusion CT in diagnosing and staging neck masses, suggesting it as a valuable tool for improving diagnostic accuracy and treatment planning.
Authors: Nishat Amina, Satya Prakash, Mankirat Singh
Institutions: Lady Hardinge Medical College, Fortis Healthcare
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405977988