Spectrophotometric determination of Hydrochlorothiazide by diazotization- coupling using a meta-aminophenol reagent and application to pharmaceutical formulations.
Year: 2025
Type: article
Abstract: A Spectrophotometry method was developed to be faster and more sensitive to determine the purity of Hydrochlorothiazide compound. This method is relying on the reaction of diazotization- coupling using a meta-aminophenol reagent medium and factor to give a yellow product at the wavelength 443 nm. This is will be within the range of Beer's law (0.4-20 ppm), molar absorbance (3.7843×104 L.mol-1.cm-1), correlation coefficient (0.9998), and Sandell?s sensitivity (0.00786 µg/cm2) Limit of detection (LOD) (0.0226 ppm) and LOQ (0.0754 ppm). It has been successfully applied to pharmaceutical preparations...
Source: NTU Journal of Pure Sciences
Author: Farha Khalaf
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4405981363