“Tissue and/or Serum Expression levels of miRNA-31 and miRNA-141 as potential diagnostic markers for Colon Cancer in Egyptian Patients”
Year: 2024
Type: article
Study design: Observational Study
Abstract: Cancer colon is the most common cancer of the digestive tract representing the third most common cancer. MiRNAs regulate 30% of human genes. They can act as oncogenes and tumor suppressors. MiRNA-31 expression level is altered in many cancers; it is increased in squamous cell carcinoma, and hepatocellular carcinoma, but significantly decreased in gastric, breast, and prostate cancer. MiRNA-141 is an important member of the miR-200 family regulates different cellular processes, such as proliferation and angiogenesis. The study aimed to determine the tissue and serum expression of miR-31 and miR-141 in Egyptian patients with cancer colon. Fifty subjects were enrolled in this study. They were divided into 2 groups; Group I: 25 newly diagnosed stage II and III primary cancer colon patients, and Group II: 25 healthy controls. Increased expression of miRNA-31 in cancerous tissue more than adjacent noncancerous tissue was observed. Regarding miRNA-141; there was a significant increase in serum miRNA-141 in cancer colon group than the control group. A ROC curve showed that AUC for serum miRNA-141 was 0.869. This suggests the possible use of serum miRNA-141 in diagnosis of CC.
Authors: Noha Said Kandil, mohamed abdelrahman, mohamed kamel, mohamed shamsya, Mona Abdel Ghany Haiba, Maher A Kamel, thanaa moghazy
Institution: Alexandria University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4405984843